Publicaties

Na het onderzoek van Prof Moussa, zijn er talloze onderzoeken gestart naar de werking van dit speciale molecuul.  Hieronder hebben we een aantal samenvattingen in Engels geplaatst met verwijzing naar de originele publicatie.

 

The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.

Abstract

Countless studies showed that [60]fullerene (C(60)) and derivatives could have many potential biomedical applications. However, while several independent research groups showed that C(60) has no acute or sub-acute toxicity in various experimental models, more than 25 years after its discovery the in vivo fate and the chronic effects of this fullerene remain unknown. If the potential of C(60) and derivatives in the biomedical field have to be fulfilled these issues must be addressed. Here we show that oral administration of C(60) dissolved in olive oil (0.8 mg/ml) at reiterated doses (1.7 mg/kg of body weight) to rats not only does not entail chronic toxicity but it almost doubles their lifespan. The effects of C(60)-olive oil solutions in an experimental model of CCl(4) intoxication in rat strongly suggest that the effect on lifespan is mainly due to the attenuation of age-associated increases in oxidative stress. Pharmacokinetic studies show that dissolved C(60) is absorbed by the gastro-intestinal tract and eliminated in a few tens of hours. These results of importance in the fields of medicine and toxicology should open the way for the many possible -and waited for- biomedical applications of C(60) including cancer therapy, neurodegenerative disorders, and ageing.

Link naar de publicatie van het onderzoek: The prolongation of the lifespan of rats by repeated oral administration of [60]fullerene.

Link to full document: (PDF download)

PRISTINE C60 fullereneS inhibit THE RATE OF TUMOR GROWTH AND METASTASIS

Link naar de publicatie van het onderzoek: http://exp-oncology.com.ua/article/1776 

Summary. Aim: To estimate the impact of C60 fullerene aqueous solution (C60FAS) on the rate of transplanted malignant tumor growth and metastasis. Methods: Lewis lung carcinoma was transplanted into С57Bl/6J male mice. Conventional methods for the evaluation of antitumor and antimetastatic effects have been used. Results: The C60FAS at low single therapeutic dose of 5 mg/kg inhibited the growth of transplanted malignant tumor (antitumor effect) and metastasis (antimetastatic effect): the maximum therapeutic effect was found to be of 76.5% for the tumor growth inhibition; the increase of animal life span by 22% was found; the metastasis inhibition index was estimated as 48%. Conclusion: It was found that water-soluble pristine С60 fullerenes efficiently inhibit the transplanted malignant tumor growth and metastasis. (PDF download)

Fullerenes and Viruses

L. B. Piotrovsky & O. I. Kiselev(2006)Fullerenes and Viruses,Fullerenes, Nanotubes and Carbon Nanostructures,12:1-2,397-403,DOI: 10.1081/FST-120027198

Abstract

It is well known that any, sometimes very small, changes in the chemical structure can lead to the dramatic changes in biological properties. Therefore it is necessary to divide into two different topics the studies of biological properties of fullerene and fullerene‐like compounds. In the enormous variety of data on the biological activity of fullerenes it is possible to select some with defined mechanism of action. This selection showed that in case of using the fullerene‐containing compositions the main mechanisms of drug action, namely unspecific, specific (ligand–receptor) interaction and membranotropic can be obtained. Therefore fullerenes as compounds with broad biological potential are very promising not only for the design of antiviral compounds, but also for the design of various types of drugs.

Keywords: FullereneVirusC60 PVP complexBiological properties

https://www.tandfonline.com/doi/abs/10.1081/FST-120027198

 

Pristine Fullerene C60: Different Water Soluble Forms—Different Mechanisms of Biological Action

Aqueous fullerene preparations, namely complex of C60 with polyvinylpyrrolidone (C60/PVP) and molecular‐colloidal water solutions of C60 (FWS) exhibit virucidal activity due to different mechanisms: C60/PVP complexes act mainly on the lipid component of virus membranes, while the mechanism of virocidal action of FWS is mainly connected with the ability of fullerene to generate singlet oxygen under irradiation. In the first case, fullerene acts mainly as a membranotropic agent, whereas in the second case it acts mainly as a photosensitizer.

https://www.tandfonline.com/doi/abs/10.1080/15363830600665375?journalCode=lfnn20

Protective effects of nanostructures of hydrated C60 fullerene on reproductive function in streptozotocin-diabetic male rats

“In conclusion, we have presented for the first time substantial evidence that administration of C60HyFn significantly reduces diabetes-induced oxidative stress and associated complications such as testicular dysfunction and spermatogenic disruption.”

Link naar de publicatie van het onderzoek: https://www.sciencedirect.com/science/article/pii/S0300483X10006554